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A phylogenetic tree showing the evolutionary relationships among 271 vertebrate species whose genomes were assembled by the Vertebrate Genomes Project

The Vertebrate Genomes Project (VGP), powered by Galaxy running on the IU-led Jetstream2 cloud computing resource, has produced 272 near error-free genome assemblies spanning 271 vertebrate species and 518 haplotypes.

Galaxy and Jetstream2: A Powerful Partnership

Producing genome assemblies at this scale and quality requires enormous computational resources. Galaxy, running on Indiana University’s Jetstream2 cloud, provided the infrastructure to make it happen. Jetstream2’s large-memory nodes (up to 1 TB of RAM) were critical for the memory-intensive steps of genome assembly, while its scalable cloud architecture allowed the VGP to process hundreds of genomes efficiently.

Galaxy’s accessible, web-based interface meant that researchers worldwide, including those without deep computational expertise, could participate in the assembly and analysis process. This combination of scalable cloud computing and an open, user-friendly platform was key to the project’s success.

“These assemblies open the door to understanding the biology of species that have never had a reference genome. For non-model organisms, this changes everything.” — Giulio Formenti, Rockefeller University, VGP

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Read the full story on IU News: Jetstream2 helps map high-quality genomes for hundreds of vertebrate species.