Datatypes and Tools
This is usually a simple datatype assignment incompatibility between the dataset and the tool.
Expected input datatype format is explained on the Tool form itself within the parameter settings and help text.
Convert Format or modify the datatype using the dataset's icon to reach the Edit Attributes form.
Many attributes can be edited on these forms, including datatype, database, and other metadata.
You may need to first create a Custom Build and assign that as a database when using a Custom Reference Genome.